Calming the Over-Active Immune Response
An over-active immune system can result in seasonal challenges. However, there are a variety of nutrients which may offer support for immune system balance.
Bioflavonoids are great antioxidants which help stabilize mast cells and help balance histamine levels. Quercetin and luteolin, are two great options.* Note that luteolin has a half-life of less than five hours, which means it’s necessary to take it multiple times a day to maintain levels in systemic circulation.
Nettles have a long history of traditional use for seasonal challenges. Nettles also support histamine balance, but through a mechanism different from bioflavonoids. That’s why formulas often combine nettles and flavonoids for synergistic effect.
EPA and DHA are important foundations for supporting a balanced immune system.*
Vitamin C supplementation has been shown to help balance histamine levels and is often used in combination formulas that include the aforementioned flavonoids.*
B Vitamins and Minerals
B vitamins and minerals are essential to the metabolism or breakdown of histamine, specifically vitamins B1, B6, B5, B12 and folate as well as magnesium, copper and vitamin C. Note that the first step in the primary histamine metabolism pathway involves methylation and if your patient is a poor methylator, this could impede the breakdown of histamine. Make sure your patients are replete in these nutrients.*