Curcumin Supports Healthy Inflammatory Response*
When the inflammatory response continues unchecked, it can impact nearly every organ and system in the human body. That’s why supporting a healthy systemic inflammatory response has broad reaching health effects. In addition to diet and lifestyle, curcumin offers dietary supplement support for healthy inflammatory response.*
According to a 2013 article in the Journal of the American Association of Pharmaceutical Scientists, “Curcumin’s pleiotropic activities emanate from its ability to modulate numerous signaling molecules such as pro-inflammatory cytokines, apoptotic proteins, NF–κB, cyclooxygenase-2, 5-LOX, STAT3, C-reactive protein, prostaglandin E2, prostate-specific antigen, adhesion molecules, phosphorylase kinase, transforming growth factor-β, triglyceride, ET-1, creatinine, HO-1, AST, and ALT in human participants.”*
Subsequent research has confirmed curcumin’s action on these pathways and identified even more ways in which curcumin supports a healthy systemic inflammatory response in the human body.* In fact, a 2017 review published in the Journal of Traditional and Complementary Medicine identified 16 different mechanisms of action associated with curcumin.
Human clinical trials have been conducted among a wide variety of patient populations. A 2016 systematic review and meta-analysis of randomized clinical trials published in the Journal of Medicinal Food clearly demonstrated that curcumin can support joint health.* A 2018 double-blind, placebo-controlled study published in the American Journal of Geriatric Psychiatry showed that curcumin can help support mood and memory via supporting healthy inflammatory response in the brain.*
A 2018 review of preclinical and clinical studies featured in the Journal of Nutrition & Intermediary Metabolism concluded that curcumin helps support healthy blood sugar levels partly through supporting healthy inflammatory responses.* Also in 2018, a study using magnetic resonance-based electrical conductivity imaging that was published in the journal Mediators of Inflammation found that curcumin supported liver health through supporting healthy inflammatory response.*
As good news about curcumin continues to pile up in the scientific literature, your patients don’t have to wait to experience the benefits. There are many great curcumin products available to meet a variety of needs!
Daily JW, Yang M, Park S. Journal of Medicinal Food. 2016;19(8):717-729.
Fadus MC, Lau C, Bikhchandani J, Lynch HT. Journal of Traditional and Complementary Medicine. 2017;7:339-346.
Gupta SC, Patchva S, Aggarwal BB. The AAPS Journal. 2013;15(1):195-218.
Kyung EJ, Kim HB, Hwang ES, et al. Mediators of Inflammation. 2018;2018.
Rivera-Mancia S, Trujillo J, Chaverri J. Journal of Nutrition & Intermediary Metabolism. 2018;14:29-41.
Small GW, Siddarth P, Li Z, et al. The American Journal of Geriatric Psychiatry. 2018;26(3):266-