New Study Shows Garcinia Extract and Glucomannan Can Help with Weight Loss
Garcinia cambogia is a fruit with a high concentration of hydroxycitric acid (HCA), which has been shown in clinical studies to significantly reduce visceral, subcutaneous, and total fat in human subjects. HCA is an inhibitor of adenosine triphosphate citrate lyase and hence, has the potential to inhibit lipogenesis. Glucomannan is a fiber that is able to absorb 50 times its weight in water volume. Glucomannan creates a feeling of satiety which may help reduce appetite.
A recent 2018 study featured in the journal BMC Complementary and Alternative Medicine evaluated the weight loss effects of Garcinia extract and Glucomannan on 214 overweight or obese individuals. Participants were advised to have a balanced diet (Mediterranean diet), regular meals and intake of plenty of water. The study participants were given 500 mg of Garcinia cambogia extract (52.4% HCA) and 500 mg of Glucomannan twice a day, one half hour before lunch and dinner for six months. In addition to monitoring weight, the researchers also looked at fat mass, visceral fat, and basal metabolic rate, as well as lipid and glucose blood profiles. They also identified patients who carried the following polymorphisms:
- PLIN4 -11482G > A-
- fat mass and obesity-associated (FTO) -rs9939609 A/T-
- β-adrenergic receptor 3 (ADRB3) -Trp64Arg
Results showed weight loss and reduced fat mass, visceral fat, lipid and blood glucose profiles and increased basal metabolic rate. “We found a dramatic, highly significant and sustained reduction of weight at 3 and 6 months compared with the start of the study,” concluded the researchers. Weight loss was independent of sex, age, hypertension, type 2 diabetes, or dyslipidemias.
This study also found that the patients with the polymorphisms had less visceral fat and total fat mass loss than those without the polymorphisms. The researchers confirmed that their results are consistent with other studies demonstrating that patients with the PLIN4 polymorphism in particular respond less to weight loss treatments in general. The researchers report that previous studies also show that people who carry the FTO and ADRB3 polymorphisms lose weight, fat mass, and visceral mass at a slower rate than those who do not have these polymorphisms.
This study is important in that it helps explain why some patients do not respond as well as others to various weight loss interventions. For patients without these polymorphisms, the combination of Garcinia extract and Glucomannan has the potential to support significant weight loss, which may be worth considering when achieving a healthy body weight is an important clinical goal.
Also of importance to note, is that like many other dietary supplements, when it comes to Garcinia, more is not better. Intake should not exceed manufacturers recommended dosage, and Garcinia extract is contraindicated for use in patients with compromised liver status.
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